In 2007, Lil Wayne made a brief but memorable appearance in the golf comedy Who's Your Caddy? Starring Kevin James and Nick Frost, the movie follows a caddy who tries to make a career for himself in the world of golf. Lil Wayne appears as himself, a rapper who is invited to play in a celebrity golf tournament.
Lil Wayne took on a more serious role in the 2009 thriller Hurricane Season, directed by Rob Cohen. The movie follows a group of hurricane chasers who find themselves trapped in the path of a devastating storm. Lil Wayne plays the role of "The General," a former soldier who leads the group in their desperate attempt to survive the hurricane.
Lil Wayne made a guest appearance on the sitcom Grandfathered in 2015. The episode, titled "The Weezy Factor," features Lil Wayne as himself, a music producer who helps the show's main character, Jimmy, with his music career.
In 2020, Lil Wayne was featured in the Netflix documentary Unsung, which profiles the lives and careers of unsung music legends. The episode about Lil Wayne delves into his early life, his rise to fame, and his ongoing impact on hip-hop culture.
In 2023, Lil Wayne starred in a remake of the classic 1990 party movie House Party. The remake, directed by Reginald Hudlin, follows the same storyline as the original, but with a fresh cast and modern setting. Lil Wayne plays the role of "Big Perm," the neighborhood hustler who hosts the epic party.